Brežice is a city and municipality in eastern Slovenia in the Lower Sava Valley. The Lower Sava Valley Museum (Slovene: Posavski muzej Brežice), housed in Brežice Castle, contains archaeological and ethnological exhibits, exhibits on the Croatian and Slovenian peasant revolt, and a modern history collection. It is one of the largest regional museums in the country. A more recent landmark addition to the town is its water tower, as well as the double arches of the 527 m long iron bridge, which spans the Sava and Krka rivers. The area's many hot springs have contributed to the development of the largest natural spa and the second largest tourist center in Slovenia, Čateške Toplice (the Terme Čatež Thermal Health Resort). Brežice also offers visitors recreation and entertainment, as well as sports including hunting and fishing. The surrounding hills are ideal for fruit growing and viticulture. The vineyards of the Bizeljsko and Pišece districts are renowned for their top-quality wines.

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